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Why higher dose of Prep

Hi, I am male. If Descovy with tenofovir alafenamide of 25 mg is FDA approved and working fine as Prep then why we are still prescribed and taking 300 mg of Tenofovir?

Is tablet of emtricitabine 200 mg and tenofovir alafenamide 25 mg enough as on demand prep?

  1. Hi . I want to make sure I understand your question. Are you asking if a person would still need to take Truvada (tenofovir disoproxil fumarate 300 mg/emtricitabine 200 mg) if one is taking Descovy? Or are you asking if Descovy should replace Truvada? There are medical reasons a doctor would prescribe each drug relative to an individual case. I need to note that we are not medical professionals and cannot offer prescribing advice. Concerning your second question, one tablet of Descovy (emtricitabine 200 mg and tenofovir alafenamide 25 mg) daily is the recommended dosage for adults and adolescents weighing at Least 35 kg (see: https://www.drugs.com/dosage/descovy.html). Hope this information is helpful. Best, Richard (Team Member)

    1. Hi Richard, I'm asking regarding Descovy or its generic version with composition emtricitabine 200 mg and tenofovir alafenamide 25 mg as Prep.


      I'm a male and mostly involve in sexual activity (vaginal) with different female through hookup at different time. These girls might also involve with different male in different time.


      So I was thinking that is Prep with emtricitabine 200 mg and tenofovir alafenamide 25 mg composition is enough as on-demand prep or daily prep.

      1. Thanks for detailed information and links.
        I also found this on same article "Descovy was approved in 2019 as a second daily PrEP option, but not for people who are exposed to HIV via vaginal sex, due to a lack of research."


        So this is what understood "descovy is not okay as OnDemand Prep or Daily Prep for male involved in vaginal sex with female." Am I write?


        Or lack of data means "If it's working for bi male then maybe it have same or similar results for straight male too"? If the male here is giver, not receiver.

      2. Hi . My understanding of the full quote on Descovy is that it is only approved for daily prep and that the results for the study of on-demand prep did not apply to Descovy. That said, it would be useful, if you have a professional you trust, to have a discussion on what drug is best for you. Best, Richard (Team Member)

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